Lipid Extract From a Vegetable (Sonchus Oleraceus) Attenuates Adipogenesis and High Fat Diet-Induced Obesity Associated With AMPK Activation

Scope: Sonchus Oleraceus , named bitter vegetable (BV), has been known to have multiple health benefits such as anti-aging and anti-inflammation. However, the role of BV in prevention obesity is unclear. The aim this study was examine effect lipid extracts (BVL) on development. Methods Results: Following treatments high fat diet-induced obese mice (C57BL/6J) with BVL (0.3 mg/g BW per mouse) for a month, exhibited significant reduction weight gain, blood triglyceride, fasting glucose compared control mice. Intriguingly, phosphorylated AMPK, key regulator nutrient metabolism, markedly increased inguinal group. In 3T3-L1 cells, BVL-7 (100 ?g/ml), an omega-3 fatty acid-rich fraction from BVL, lowered accumulation, down-regulated gene expression adipocyte markers. inhibitory occurred at early stage differentiation, leading delay mitotic clonal expansion. AMPK knockdown by siRNA abolished adipogenesis, suggesting that essential BVL-regulated differentiation. Conclusion: can effectively inhibit adipogenesis through, least part, stimulating pathway attenuate HFD-induced obesity. Our findings suggest be promising dietary supplement protection against obesity, effective component potentially developed anti-obesity drugs.